Endocrine Abstracts

The experience and expertise of a thyroid surgery team is a relevant factor in the development of postsurgical hipoparathyroidism (hypoPP). In 2005, we published a 9.6% prevalence of permanent hipoparathyroidism among patients operated on for thyroid cancer (TC) at our centre between 1985 and 2001. Since 2002, an expert surgery team was implemented as part of a multidisciplinary committee. The aim of the present study is to assess the prevalence and risk factors associated wit...

Background: CV-PTC is often indolent with excellent long-term response, while TCV-PTC (≥50% of tall cells) have aggressive features and worse clinical behavior. Less is known about the clinical behavior of CV-PTC with tall cells <50% (TC/CV-PTC) that, so far, is considered as low risk tumor.Aim: To evaluate the histological presentation of CV-PTC, TC/CV-PTC, TCV-PTC and their clinical behavior after 6 years of follow up.M...

Background: The management of subclinical hypothyroidism (SH) is still challenging in particular for mild forms with TSH levels ranging between 4.5 and 10 mU/L. Although SH in children seems to be a bening condition, ongoing scientific investigations have highlighted the presence of subtle proatherogenic abnormalities among children with modest elevations in their TSH levels. Data on cardiac performance in children with SH are still scanty.Aim: To compar...

Introduction: Simple aspiration is the first-line treatment used for benign cystic thyroid nodules. However, a high recurrence rate has been reported with this procedure. When this happens, percutaneous ethanol injection into the nodules has proven to be an effective technique which can reach a volume reduction of about 85% (Kim et al., Eur Radiol. 2012 Jul;22(7):1573–8).Material and methods: Descriptive analysis of percutaneous 96° et...

Laser ablation of thyroid nodules has been used for the last two decads (Pacella et al, 2000). Surprisingly, complications are less frequent in patients treated without anesthesia, probably because eventual pain is an useful alarm symptom, leading the operator to repositioning the fiber during the procedure (Pacella et al., 2015).Material and methods: A total of 32 patients were included, without using local anesthesia. Nodules were solid, 5–72 ml v...

Introduction: Fine needle aspiration cytology (FNA) is the most accurate diagnostic method for thyroid malignant nodule diagnosis. According to the literature, the percentage of false negative results (FN-FNA) is less than 1.5%, in tertiary health care centers.In this study we describe the cases reported in this Hospital, between 2014 and 2016, of benign cytology, histologically characterized as malignant. All pathologic specimens were reviewed.<p cl...

Patients with chronic hypoparathyroidism (HypoPT) treated with oral calcium and active vitamin D metabolites are at risk of renal complications, because of the lack of action of PTH at the renal tubule. In the present study we evaluated 90 patients (68 females and 22 males; age: 51.8±14.1 yrs) with chronic postoperative Hypo (PO-HypoPT) diagnosed since at least 3 years. All patients were treated with calcitriol and 35 (39%) with oral calcium two patients were also treated...

Introduction: 131I-iodide therapy (RIT) is an important treatment modality for patients with differentiated thyroid carcinoma (DTC). However, despite the overall excellent outcome, some DTC patients with poor prognosis may require multiple doses of radioactive iodine.Aim: The purpose of our study was to evaluate the efficacy of cumulative doses (CDs) of RIT in metastatic DTC patients.Material and methods: A retrospective study was ...

Ethanol and laser ablation of benign thyroid nodules is bursting rapidly in clinical practice because of its efficacy, safety and economy. However, these techniques require some manual operator training. In order to facilitate this hands-on training, we propose two homemade, cheap and specific simulators to practice these clinical procedures.Material and methodsTwo models were optimized: Gel-Phantom Coruna VR16 (gelatine a...

Although the effect of aging on adipose tissue metabolism have been thoroughly studied for years, changes in the antilipolytic action of insulin in visceral white adipose tissue from aged rats are still not completely understood. By fact, some contradictory data on the inhibition of isoproterenol-induced lipolysis by insulin with aging have been reported. As aging is a significant risk factor for increasing adiposity and the development of obesity, we hypothesized that the inh...